The bank is closing 140 branches across the country.
The Ramsbottom branch will close in June.
More than 12-hundred jobs are at risk - but the bank says it hopes to offer new roles to around a third of those affected.
The Spanish-owned company says it's making changes because more banking is done online and via apps.
In the last few years Ramsbottom has lost it's branches of Natwest and RBS.