Shortly before 5.30am today, police were called to reports of a collision between a car and a pedestrian on Wigan Road in Bolton.
Emergency services attended and a 47-year-old man has been taken to hospital with serious injuries.
The driver remained at the scene to speak with officers and no arrests have been made.
A number of roads were closed but they have since reopened.
Enquiries are ongoing.
Anyone with information should call police on 0161 856 4741 or 101 quoting incident number 342 of 13/02/2020, or the independent charity Crimestoppers, anonymously, on 0800 555 111.