Senior officers from Greater Manchester and Merseyside will join counterparts from other forces at a meeting with the home secretary Sajid Javid this morning.
It follows the death of two teenagers who were stabbed to death in London and Greater Manchester.
Two boys of 17 have been charged after the fatal stabbing of another 17-year-old on Saturday evening.
Yousef Makki died in hospital after being attacked in Hale Barns.
Meanwhile last night a man was arrested after the death of 17 year old Jodie Chesney - who was stabbed in east London on Friday night.
Greater Manchester Police’s Assistant Chief Constable Rob Potts said: “The events of this weekend have sadly raised so many questions about the state of the knife crime problem in Greater Manchester and across the country.
There is no denying it is a problem for society and one that the police, local authorities, health and education providers are working hard to address.
The only way to properly tackle this problem is by working together with communities and our partners.
“Greater Manchester Police will be continuing to run operations to tackle knife crime over the coming weeks and months, incorporating a range of policing tactics including hotspot targeting and stop and search methods as well as working with partners to better understand why people are carrying knives while educating them of the consequences of doing so.
“The problem of knife possession is not going to be properly resolved quickly but I hope that the tragic loss of a 17-year-old boy’s life will bring home to people the potential outcome that follows from the carrying and use of knives.
“I also hope parents will also take note and open up that conversation with their children about carrying knives - better an awkward conversation now than a devastating one later.”