Bury New Road which runs through Prestwich to the M60 has appeared in the top ten most congested routes in the UK.
Travel firm Inrix has calculated how much time people spend stuck in traffic and how much it costs.
Bury New Road, which runs from Higher Broughton to the M60 through Prestwich sees drivers waste around 34 hours a year in traffic.
Nationally the average road user in London lost up to £1,680 due to jams.
This was followed by Edinburgh (£1,219), Manchester (£1,157) and Leicester (£1,145).
The mayor of Greater Manchester Andy Burnham has made congestion and air pollution one of his top priorities and is considering several options including clean air zones.
However Lid Dem councillors in Bury are blaming the authority for the problems.
Michael Powell, Liberal Democrat candidate in St Mary’s Ward which covers the A56 right through Prestwich said:
"It’s appalling that Prestwich has the most congested road int he North West and the 10th worst anywhere in the country. The study estimates that each year a Bury New Road driver will lose 34 hours of their life to the additional congestion - that's nearly a week at work!
"Standing traffic, particularly large diesels like buses and lorries, is one of the worst causes of air pollution.
"Our view is that the Council is failing to tackle this congestion, made it worse with all the parking bays through the village, and failed to address the series problems with rat runs throughout Prestwich that the congestion has caused.
"People are demanding action and the Council is letting us down.”